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by Michael J. Shapiro | March 01, 2011

This colorful city is best explored in chunks, one neighborhood at a time.

Santa Fe, on the city's western edge, is a bustling business district, heavily populated with glass and steel edifices. The Westin Santa Fe opened in August, a 259-room hotel with more than 12,000 square feet of meeting space, a short walk from the Expo Bancomer.

The more centrally located St. Regis debuted one year earlier. On the city's famed Paseo de la Reforma, the distinctive 189-room, César Pelli-designed tower offers the brand's signature luxury in a modern, elegant and welcoming setting, along with nearly 13,500 square feet of event space.