Skilled skillet.
Trevett Hooper, executive chef and owner of Legume, was named Chef of the Year by Pittsburgh magazine for good reason: His celebration of local Western Pennsylvania ingredients has earned the bistro high marks and a devoted following. A popular staple is Chicken Cooked Under a Skillet, made with garlic, roasted potatoes and poultry from the East Liberty Farmers' Market.
legumebistro.com 
Andy's art. In a renovated warehouse, the Andy Warhol Museum is devoted to the life and work of Pittsburgh's most famous artist son. Works of Warholia from the museum's extensive archives are displayed in rotation. Special exhibitions include a retrospective of Shepard Fairey (famous for the "Hope" image of then-Candidate Obama), which runs through the end of January. warhol.org
Come hungry. Primanti Brothers debuted in the 1930s, serving sandwiches to truckers from a cart. Today, the local chain of 18 restaurants is famous for topping all of its sandwiches with tomatoes, cole slaw and French fries. Visit the original 24-hour eatery on 18th Street, and try the Pitts-Burgher cheesesteak. primantibrothers.com
Sideways. The Duquesne Incline, dating from 1877, is a two-cable-car "funicular railway" that climbs, mountain goat-style, right up the side of Pittsburgh's Mt. Washington, to 400 feet above the Ohio River. Consider the $2 one-way fare as admission to a stunning panoramic view of the city. incline.cc
At the hub of the Three Rivers Heritage Trail, Golden Triangle Bike Rental offers bicycles (from April–October, starting at $8 an hour and $30 a day) for exploring Pittsburgh via 20 miles of urban trails. Guided group tours are available. bikepittsburgh.com